岭南心血管病杂志

弓和胸腹主动脉动脉瘤的去支、开窗、带支内支架的联合治疗(Hybrid)临床经验

关键词: 内支架治疗  主动脉外科  腹主动脉瘤  胸主动脉瘤  臂动脉  主动脉弓  外科手术  肾动脉  支架植入  主动脉病变  

目的介绍弓和胸腹主动脉动脉瘤的去支,开窗,带支内支架的联合治疗(Hybrid)临床经验。方法德国心脏中心柏林1995年开始使用主动脉内支架治疗主动脉瘤800余例,其中多为肾动脉下腹主动脉瘤和胸主动脉瘤。2009年开始头臂动脉去支,主动脉弓部植入内支架的联合方法治疗主动脉弓部瘤。根据弓部瘤的不同部位,先进行外科左锁骨下动脉-左颈动脉-头臂动脉外...

等级管理对高血压社区综合防治的促进作用

关键词: 高血压防治  社区综合防治  等级管理  社区防治  促进作用  社区卫生服务机构  服务项目  评定标准  高危人群  公共卫生  

1等级管理产生的背景我国新医改中已将高血压、糖尿病纳入基本公共卫生服务项目,这表示高血压社区控制已成为我国社区卫生服务的重点工作之一。目前全国各地数以万计的社区都在如火如荼地开展高血压

前言

关键词: 全体工作人员  会议论文  心血管病  专家学者  平台  组委会  血管研究  中国南方  理论知识  学术文章  

光阴荏苒,转眼又一年,对于整个历史长河来说,一年只不过是沧海一粟。而中国南方国际心血管病学术会议(南方会)全体工作人员13年来始终站在这里,热情地期待着每一位致力于心血管研究的专家、同道们,藉会议的平台,探讨心血管事业的发展。

糖尿病社区管理

关键词: 糖尿病酮症酸中毒  糖尿病患者  糖尿病并发症  急性并发症  糖化血红蛋白  微血管并发症  诊断  胰岛素  综合医院  慢性并发症  

糖尿病是由于胰岛素作用抵抗和(或)胰岛素分泌缺乏所致的一组以慢性高血糖为特征的代谢疾病,可伴有蛋白质、脂肪代谢异常。严重的高血

儿童高血压

关键词: 高血压诊断  儿童高血压  儿童青少年  原发性高血压  肥胖儿童  心血管病  主动脉缩窄  百分位  儿童血压  高血压危象  

1概述根据2009年的《中国心血管病报告》,我国18岁以上高血压人口估计至少有2亿。已经成为名副其实的高血压人口大国。其原因之一与我们忽略了不断进入高血压人口大军的儿童青少年高血压的防治有一定关系(从国家"六五"至"十一五"只有针对成年人群的高血压的防治策略)。将高血压防治窗口"下移"到儿童青少年人群,是

妊娠期高血压疾病的降压治疗

关键词: 妊娠高血压  妊娠期  降压治疗  慢性高血压  疾病  子痈  甲基多巴  新生儿  发病率  尼卡地平  

妊娠期高血压疾病是产科最常见的并发症,也是导致孕产妇和围产儿发病率和死亡率增加的常见原因之一。目前妊娠期高血压疾病的定义和分类仍存在争议。中国过去将妊娠期高血压、先兆子痫、子痫统称为妊娠高血压综合征(简称妊高征,PIH)。2000年美国高血压工作组提议将妊娠诱发高血压和妊娠前已有高血压统称为妊娠期高血压疾病(pregnancy-induced hy...

临床观察性研究在疗效比较研究中的应用

关键词: 比较研究  随访研究  干预措施  病例对照研究  临床疗效  循证医学  不同治疗  临床决策  研究者  研究对象  

1疗效比较研究概念深化医疗卫生体制改革和有效提升卫生保健服务效率是全球性难题。美国基于企望阻遏医疗卫生费用膨胀,提高卫生保健服务效益比的'疗效比较研究(CER)',在全球经济危机背景下出笼。疗效比较研究(Comparative Effectiveness Research,CER)指在实际医疗环境中(in'real world'settings),比较不同治疗方法及预防、诊断、治疗和健

心血管疾病与焦虑抑郁障碍

关键词: 心血管疾病  焦虑抑郁障碍  躯体症状  焦虑抑郁症状  精神科  患者  广泛性焦虑障碍  躯体疾病  抗焦虑  综合性医院  

焦虑、抑郁障碍具有高发病、高复发、高致残、症状重、慢性化、需要更多的医疗服务等特点,是医疗资源的沉重负担。由于焦虑抑郁障碍患者常因各种情绪相关性躯体症状,反复求诊于各临床科室,而成为基层医疗资源的高频率使用者。研究发现焦虑障碍所花的医疗费用大约是一般人口的9倍。据调查,在医疗资源利用率高的人群中,40%为抑郁障碍患者,21.8%为...

医学科研课题及申报要领

关键词: 科研课题  技术路线  研究领域  申请书  研究内容  医学科研  研究方法  研究目标  设计方案  研究对象  

医学科研课题是探索解决医学研究领域中某一科学技术问题而提出设想及其依据,提出目标并设计实施方法与步骤的一个最基本的研究方案与框架。1医学科研课题的形成必须具备的条件(1)科学研究的意识和科学探索的精神;(2)

肾上腺素受体非经典信号途径参与病理性心肌重塑

关键词: 肾上腺素受体  心肌重塑  信号途径  非经典  病理性  心衰  血管新生  交感神经  心脏血管  激活  

心力衰竭是一种致残性慢性疾病,它是老年人致病和致死的一个主要原因。心衰病人有着不同的致病因素,但是慢性交感神经和β-肾上腺素受体(β-AR)的激活是心衰发生时共有的现象。慢性交感神经和β-AR的激活对心脏是有害的,在心衰恶化、心脏功能异常和心肌重构进展中发挥重要的作用。交感-儿茶酚胺系统通过直接激动

PP4介导了炎症引发的肝胰岛素抵抗

关键词: 胰岛素抵抗模型  糖原合成  信号通路  糖异生  活性变化  表达载体  表达水平  高表达  磷酸酶活性  相互作用  

我们首次探讨PP4在炎性因子TNF-α和IL-6诱导的胰岛素抵抗中的作用与调控机理。从新的视点为揭示胰岛素抵抗的发生机制奠定了基础,为2型糖尿病及其并发症的防治提供了新的

Differentiation of rat embryonic stem cells into functional cardiomyocytes

Rats(Rattus norvegicus) have many advantages over mice in scientific studies,for example, they are more relevant to human in physiological and pharmacological responses.Therefore,rats are broadly used in experimental studies.The recent breakthrough in the generation of rat embryonic stem cells(rESCs) opens the door t...

Current issues and innovations in stem cell based therapy

It is well established that stem cells can differentiate into cell types of the organ in which these are transplanted.However,the process is very slow due to lack of understanding of signals important for their survival and differentiation,most optimal stem cells and their plasticity.Limitations and advantages of var...

Transfusion of CXCR4-priming endothelial progenitor cells reduces cerebral ischemic damage and promotes angiogenesis and neurogenesis in db/db diabetic mice

Previous studies suggest that reduction and dysfunction of circulating endothelial progenitor cells(EPCs),and dysregulation in stromal cell derived factor-1/CXC-chemokine receptor 4(SDF-1/ CXCR4) axis in diabetes could be therapeutic targets for diabetic ischemic stroke.This study investigated the efficacy of CXCR4-p...

Angiotensin converting enzyme 2(ACE2)as a target for cardiopulmonary disease therapeutics:A new paradigm

In spite of recent advances in treatment and control,the prevalence of CVD and pulmonary hypertension (PH) around the world has increased significantly. We believe that a conceptual breakthrough is needed and novel drug targets must be discovered in an attempt to control and treat them.ACE2,the newest member of the r...

Redox regulation of classⅡHDACs and cardiac hypertrophy

Control of cardiac excitability and arrhythmias by microRNAs

Advance in bone marrow derived cell therapy:CD31-expressing cells as next generation cardiovascular cell therapy

In the recent past,bone marrow(BM)-derived cells have been used to regenerate damaged cardiovascular tissues post myocardial infarction (MI).Recent clinical trials have shown controversial results in recovering damaged cardiac tissue. New progress has shown that the underlying mechanisms of cell-based therapy relies ...

Cell sheet therapy for myocardial infarction

Introduction Recently,bone marrow mesenchymal stem cells(MSCs) have been reported to repair chronically infracted myocardium with direct injection.However,it is very difficult to localize the injected cells onto the ischemic area to regenerate sufficient cardiac mass in the thinned scar area.To overcome the problem,w...

Functional heterogeneity of high density lipoproteins and its future therapeutic indication

The atheroprotective effect of HDL is well-established, the implication being that the higher the plasma levels of HDL,the bigger the benefit to all individuals.Such a supposition has led to the development of "HDL therapy".It has fast become apparent however that assuming therapeutic benefits by merely raising HDL l...

Chloride channels in vascular function and disease

Molecular regulation of vascular stem cell function in ischemic heart failure

A balance between growth and apoptosis plays a critical role in maintaining the homeostasis of cardiovascular tissues.During the development of atherosclerosis and atherosclerosis-associated coronary heart disease many environmental factors exert regulatory effects on cardiovascular cells and their progenitors.We hav...

Evaluating the role of herg potassium-channel protein in the development of heart and vasculature

The role of human ether a-go-go related gene(hERG) in electrically excitable cells has long been known.hERG currents IKr contribute to the re-polarisation phase 3 of the cardiac action potential. Mutations of this channel causes long QT syndrome. N629D hERG mutation(GFGN to GFGD) alters the pore selectivity signature...

Bony connection to vascular dysfunction and implications on hypertension

Molecular constituents encoding the cardiac pacemaker if currents

Cardiac pacemakers play critical biological functions in generating spontaneous and rhythmic action potentials.Defects in cardiac pacemaking can be life-threatening,leading to arrhythmia and sudden death.Although the hyperpolarization-activated,cyclic nucleotide-gated(HCN) channels play a prominent role in both cardi...

Genetic modifier genes for inherited heart and muscle disease

Genetic mutations in single genes lead to inherited forms of cardiac and muscle disease. Cardiomyopathy from genetic mutations may develop in early or later life and may be associated with heart failure or be asymptomatic.The range of clinical outcome with inherited cardiomyopathy within families where there is a sin...

Metabolic dysfunction and cardiovascular disease:molecular mechanisms

Obesity is a common risk factor for the development of cardiovascular disease.It is estimated that 71%of men,61%of women and 33%of children are overweight in the United States,and this trend toward increasing body mass is found world-wide as more cultures acquire a Western lifestyle.In the United States,life expectan...

CD98 modulates alloimmune responses:evidence from the CD98-deficient mouse

IGF-1,stem cells and cardiovascular disease

Cardiovascular disease is the leading cause of morbidity and mortality in the Western world,and no effective therapy has been established. Stem cell transplantation is emerging as a novel therapy for treating cardiovascular disease.However, the suitable types of the stem cells that contribute to the repair process re...

Manipulation of collagen synthesis influences progenitor cell engraftment and angiomyogenesis

Myocardial infarction(MI)results in loss of cardiomyocytes(CM) in the ischemic area of the heart followed by an inflammatory response and replacement of contractile CM with fibrosis.Myocardial fibrosis,a key contributor to cardiac dysfunction after MI,presents as a secondary response to the pathophysiological remodel...

MicroRNAs in cardiovascular diseases:From bench to bedside

MicroRNAs(miRNAs) are a novel class of endogenous,small,noncoding RNAs that regulate gene expression via degradation or translational inhibition of their target mRNAs.Functionally,an individual miRNA is important as a transcription factor because it is able to regulate the expression of its multiple target genes.As a...

Cell transplantation and cardiac recovery:myocardial regeneration from endogenous cardiac progenitor cells

Following the bone marrow or cardiac derived progenitor cells transplantation,improved left ventricular(LV) function,decreased LV remodeling, and decreased fibrosis of non-infarcted LV regions,and in some cases,the reduction of infarct scar size have been reported to occur in animal mycardial infarction(MI) models.In...

Ectopic ATP synthase in endothelial cells:a novel cardiovascular therapeutic target

ATP synthase(ATPS) produces ATP in cells and is found on the inner membrane of mitochondria or the cell plasma membrane.In this presentation, we will briefly summarize the functions of ecto-ATPS in vascular endothelial cells(ECs).Ecto -ATPS is involved in adenosine metabolism on the cell surface through its ATP gener...

中国心血管病预防指南简介

关键词: 心血管病防治  潜在危险因素  心血管病危险因素  高血压  防治指南  预防  死亡率  发病率  冠心病  心理行为因素  

近30年来,随着我国经济发展和科学技术的进步,人民的生活和医疗条件有了很大改善。从总体看,人民的健康水平明显提高,期望寿命逐年延长。但近30年的研究表明,我国人群心血管病(主要是冠心病、脑卒中和周围血管病)的发病率和死亡率逐年上升,发病年龄提前,心血管病已成为我国最重要的公共卫生问题之一。

国际重要数据库收录中国医学期刊现状与对策

关键词: 中国期刊  中国生物医学期刊  期刊编辑部  中国医学期刊  收录  文献数据库  心血管病  检索期刊  重要数据  国际检索系统  

1国际重要数据库收录中国期刊统计汇总(数据截止日期:2011-03-20)国际部汇总了美国、英国、荷兰、德国、俄罗斯、日本、波兰、菲律宾等国家28种国际重要数据库:共收录编辑部设在中国(含港台澳)的期刊2324种(其中:大陆期刊2144种;台湾期刊150种;香港期刊29种;澳门期刊1种),7295种次;其中,医学期刊610种(未含美国《乌利希期刊指南》)。

强化降脂治疗对急性ST段抬高心肌梗死患者血管内皮功能的影响

关键词: 降脂治疗  血管内皮  阿托伐他汀  心肌梗死  强化治疗  常规治疗  血脂  基质金属蛋白酶  循环内皮细胞  患者  

目的比较60 mg阿托伐他汀的强化降脂与20mg阿托伐他汀治疗相比,对急性ST段抬高心肌梗死(STEMI)患者血脂、循环内皮细胞(CEC)、hs-CRP、基质金属蛋白酶29(MMP29)的影响,探讨强化降脂对血管内皮是否有更好的保护作用。方法选取STEMI患者36例,随机分为大剂量(60 mg)组和常规剂量(20 mg)组,观察服药前、服药后1周、4周时血脂(TC、TG、LDL-C、HDL-C)...

缺血后适应在急诊经皮腔内冠状动脉成形术中的应用

关键词: 后适应  经皮腔内冠状动脉成形术  心肌缺血  术后  对照组  心律失常事件  心肌坏死  急诊  血清  静脉血  

目的动物实验已证实缺血后适应能够减少再灌注损伤,但关于它的临床研究还不多见。本研究就其在急诊经皮腔内冠状动脉成形术(PCI)中的价值作一探讨。方法 43例确诊为急性心肌梗死的患者随机分成2组:对照组(18例)接受常规PCI治疗,缺血后适应组(25例)在行PCI术时于血流开通即刻接受后适应治疗。PCI术后0、8、16、24、32、40、48和72 h取静脉血测血...

45岁以下青年女性急性心肌梗死的临床和冠状动脉病变特点

关键词: 青年女性  冠状动脉造影  病变特点  危险因素  心源性休克  急性心肌梗死  糖尿病  高血压  女性患者  血运重建  

目的回顾分析45岁以下女性急性心肌梗死(AMI)的临床和冠状动脉病变特点及C反应蛋白(CRP)与女性AMI之间的相关性,探讨AMI危险因素及CRP对青年女性AMI诊断的预测价值。方法选取2000年1月-2010年6月住院行冠状动脉造影证实为AMI的45岁以下女性患者31例的AMI患者临床资料、冠状动脉病变特点,检测CRP、血脂、纤维蛋白原、血尿酸水平,应用logistic回归...

血浆循环MicroRNA提取检测及其在冠心病的表达

关键词: 冠心病患者  检测方法  荧光检测  提取  统计学  血浆循环  健康人群  特异性引物  表达差异  差异表达  

目的建立血浆循环MicroRNA的提取检测方法,并且检测其在冠心病患者和健康人群之间的差异表达,寻找新的疾病诊断标记物。方法前期入选收取15例冠心病患者和15例健康人的血样标本,性别和年龄在统计学上没有差异,采用Trizol LS提取血浆中的总RNA,NanoDrop1000检测总RNA浓度,设计特异性引物检测hsamiR-16、hsa-miR-126的表达,采用外加cel-miR-39进行...

静脉冠脉联合应用替罗非班对急性心肌梗死介入治疗心肌灌注及预后的临床研究

关键词: 替罗非班  心肌灌注  心肌梗死  冠脉内  静脉内  梗死相关血管  术后  左室舒张末期内径  心脏射血分数  脉组  

目的研究对行急诊PCI治疗的急性ST段抬高心肌梗死患者运用不同方法(静、冠脉联合与单纯静脉内)应用血小板GPⅡb/Ⅲa受体拮抗剂替罗非班对术后梗死相关血管血流、心肌灌注、心功能和近期预后的影响。方法收集2008年10月-2010年1月在广州市红十字会医院接受急诊经皮冠状动脉介入(percutaneous coronaryintervention,PCI)治疗的66例心肌梗死患者,随...