杂志介绍
中国药理学与毒理学杂志是由军事医学科学院主管，军事医学科学院毒物药物研究所;中国药理学会;中国毒理学会主办的一本北大期刊。
中国药理学与毒理学杂志创刊于1986，发行周期为月刊，杂志类别为医学类。
主管单位：军事医学科学院
主办单位：军事医学科学院毒物药物研究所;中国药理学会;中国毒理学会
国际刊号：1000-3002
国内刊号：11-1155/R
发行周期：月刊
全年订价：￥460.00
关键词: fingolimod lysophospholipid receptor modulator tra
Lysophospholipids are small,membrane-derived lipids that act through a growing family of G protein-coupled receptors(GPCRs)that account for around 40% of the known lipid GPCRs.They comprise a range of distinct chemical structures and include glycerophospholipids like lysophosphatidic acid(LPA)and sphingoid lipids lik...
关键词: neurodegenerative disorders traditional chinese me
In the past decades,single target drugs showed less therapeutic action and more side effects in treatment of complicated diseases such as tumor,AIDS,inflammation,diabetes,stroke and neurodegenerative disorders.The reason for this is that complicated diseases have multiple pathogenesis and multiple genes or pathologic...
关键词: lysine acetyltransferases arginine methyltransfera
The altered function of any epigenetic modification also causally affects the physiological homeostasis in different pathophysiological conditions such as cancer,neurodegenerative disorders,diabetes,asthma,COPD etc.Among the different epigenetic enzymes we focus on three important classes:lysine acetyltransferases,ar...
关键词: herbal drugs salvianolic acids kaerophyllin hepati
Many patients with chronic viral or alcoholic hepatitis,or non-alcoholic steatohepatitis are in the state of chronic liver injury and inflammation and may lead to hepatic fibrosis.The major culprit of liver fibrosis is activation of hepatic stellate cells(HSCs),characterized by transformation from a quiescent phenoty...
关键词: herbal medicines drug screening chemical separatio
Herbal medicines have been attracting intensive attention with the increasing of health care.The screening and analysis of bioactive components in medicinal plants are very important for ensuring their efficacy,safety as well as quality.A conventional procedure for finding bioactive components is the chemical separat...
关键词: curcumin network pharmacology cancer ischemia angi
OBJECTIVE With the rapid development of computer technology,achievements have been gained in the research and application of computer.Network pharmacology combines biological networks and drug network integration,analysis of drug relationship with the node or network module in the network.Since many diseases are caus...
关键词: pathway natural products androg
Autophagy is an evolutionarily well conserved process in which the cellular components including damaged subcellular organelles are engulfed in autophagosome and eventually delivered to lysosome for degradation.It has been well studied that autophagy is closely implicated in many diseases such as cancer and neurodege...
关键词: multidruresistance colon cance
Multidrug resistance(MDR)develops during chemotherapy in nearly all colorectal cancerpatients.It is envisaged that reversal of MDR plays a pivotal role in the success of chemotherapy.This study investigated thepotential pharmacological action in reversing MDR in colon cancer cells by the two most potent tanshinones,n...
关键词: autophagy gouteng alkaloids neuroprotection
Abstract Macroautophagy(autophagy)is a′self-eating′machinery used by cells to degrade and recycle long-lived proteins and organelles via lysosomes.Dysregulation of autophagy plays a critical role in the pathogenesis of neurodegenerative disorders.Small molecule autophagy inducers protects against the toxic insults ...
关键词: antihypertensive herb apocynum venetum nitric oxid
OBJECTIVE The extracts of the Apocynum venetumleaves(AVLE),also known as Luobuma,is an antihypertensive medicinal herb used widely in TCM.AVLE has been reported to exert antihypertensive action by dilating the blood vessels in an endothelium-dependent and concentration-dependent manner with optimal effect seen at as ...
关键词: autophagy natural and synthetic compounds signalli
Cell death plays an essential role in the development of organs,homeostasis,and cancer.Apoptosis and programmed necrosis are two major types of cell death,characterized by different cell morphology and pathways.Accumulating evidence shows autophagy as a new alternative target to treat tumour resistance.Besides its we...
关键词: plant galactolipids inflammatory disorders
Phytomedicines have been used for treating or preventing diseases throughout human history.We have been conducting in exploration of traditional or folk herbal medicines as an attempt to identify novel phytocompounds candidates for further development into botanical supplements or drugs for inflammation related disea...
关键词: gastric cancer chemosensitizer
Gamma-tocotrienol,a member of vitamin E superfamily has attracted great attention of late for its anti-proliferative and anti-carcinogenic potential against different cancers.For example,our group had previously reported that anti-proliferative and chemosensitizing effects ofγ-tocotrienol are associated with its abil...
关键词: polyphenols cancer chemoprevention dietary epigene
Growing evidence indicates that cancer incidence across the world is not similar,and it is more prevalent in certain populations than others,suggesting the critical role for dietary and lifestyle factors.For instance cancer incidence among people from the Indian subcontinent,where most spices are consumed,is much low...
关键词: bacopa monnieri clinical study memory neuroprotect
OBJECTIVE Brahmi(Bacopa monnieri Wettst.,Schrophulariaceae)has been used in Ayuravedic medicine as a memory enhancer.We aimed at research and development of Brahmi for clinical use as the food supplement for memory improvement.METHODS The standardized extract of Brahmi has been developed.The neuroprotective effect of...
关键词: paraptosis cancer curcumin dimethoxy
Since inherent or acquired cellular resistance to various pro-apoptotic treatments often leads to therapeutic failure,a better understanding of alternative non-apoptotic pathways may facilitate the design of novel therapeutics against malignant cancer cells.Paraptosis is a cell death mode characterized by extensive v...
关键词: ganoderma lucidum polysaccharides lymphocytes macr
Recent years,our research group focused the effects of G.polysaccharides,which are extracted from fruiting body of Ganoderma lucidum,on tumor evasion from immune surveillance.The immune system in patients with tumor often fails to control tumor growth because of deficient immunogenicity of tumor cells.Deficient major...
关键词: epimedium extract breast cancer prostate
Estrogens are critical for bone health and the development of breast and prostate tissues.At menopause,our cohort studies show that naturally occurring estrogens in the body protect against osteoporotic hip fractures,but can also increase the risk of breast cancer.Extracts of Epimediumspp.is widely used to treat oste...
关键词: traditional chinese medicine pharmacology
There are pharmacological aspects that multi-herbal traditional Chinese medicine(TCM)presents unique characters,to which conventional pharmacology research methods are not applicable.Few examples to mention:The generally lower in toxicity profiles for a TCM product makes the PharmTox study methods need to be re-visit...
关键词: aging associated diseases cerebrovascular dysfunct
Increasing evidence points towards a strong association between cerebrovascular dysfunction and neurodegenerative diseases in aging population.The global disease projection indicates that the healthcare burden derived from these disease problems will continue to rise.Many traditional Chinese medicines(CMs)have been u...
关键词: anticancer drugs andrographolide derivatives
We embarked on the discovery of anticancer agents from andrographolide nearly 15 years ago.Thus far,a few lead semisynthetic compounds have been identified,but only recently we managed to pinpoint their potential molecular target.Through in silico and cell-based studies,these lead molecules have been found to bind K-...
关键词: synthetic biology recombinant microbial cells
Synthetic biology aims to engineer genetically modified biological systems that perform novel functions that do not exist in nature,with reusable,standard interchangeable biological parts.The use of these standard biological parts enables the exploitation of common engineering principles such as standardization,decou...
关键词: photodynamic therapy curcumin hypocrellin photodyn
Malignant tumors and infectious diseases are two main threats to human beings.Photodynamic therapy(PDT)is an effective approach to treat malignancies and infections through the generation of reactive oxygen species(ROS)of a non-toxic photodynamic drug(photosensitizing agent)upon light irradiation.PDT shows promising ...
关键词: anticancer agents metastasis apoptosis
Cardiovascular diseases,cancer,diabetes and neurodegenerative diseases are four major life threatening and health damaging diseases that affect a large portion of the world population at present.Although these diseases differ significantly in terms of symptoms and pathogeneses,they have one thing in common-a defect i...
关键词: natural products cardiovascular d
Numerous clinical studies have indicated that regular intake of polyphenol-rich products such as red wine and green tea is associated with a reduced risk of cardiovascular diseases.The protective effect has been attributable,in particular,to their high level of polyphenols such as flavanols and anthocyanins.The benef...
关键词: proteomics protein profiling androg
Most drugs exert pharmacological effects through interaction with their target proteins.Therefore,drug target identification is a crucial step towards the understanding of the mechanism of drug action.It is also imperative to study the pharmacodynamics of a known drug,with an aim to discover the potentially unreveale...
关键词: drugs doxorubicin drug resistance
Development of drug resistance is a challenge to chemotherapeutic success but the mechanisms remain elusive.To study cellular resistance against doxorubicin,which is a widely employed chemotherapeutic agents in the clinic against solid tumors,lymphomas and leukemias,we employed fission yeast as a model to set up a sy...
关键词: anticancer inos jnk 1
OBJECTIVE To investigate the mechanism of anticancer effect of 2-methoxystypandrone(2-MS),a natural naphthoquinone isolated from Polygonum cuspidatum Sieb.et Zucc.METHODSThree types of cancer cells were investigated in the research(A549,MCF7,B16-F10).Flow cytometer was used to determine ROS/RNS generation.Western blo...
关键词: neuropeptide adenylate cyclise forskolin
关键词: survey fresh medicinal plants usage perceptions
OBJECTIVE To gather information regarding the usage of fresh medicinal plants and users′perceptions via face-to-face interviews.To date,there is no published report of firsthand account of their usage in Singapore.Such important information may be permanently lost if not properly collated in time.METHODS Information...
关键词: hypocrellin b photodynamic therapy apoferritin nan
OBJECTIVE To prepare hypocrellin B-loaded apoferritin nanoparticles(HB-AFT NPs)for photodynamic therapy on tumor.METHODS HB-AFT NPs were prepared by taking advantage of the reversibleunfolding and refolding character of apoferritin in different pH environments.The photophysical and photobiological properties of hypoc...
关键词: pfmg1 nacre osteoblast
OBJECTIVE To investigate the effect of Pinctadafucata mantle gene 1(pfmg1)on osteoporotic bone lossand the role in osteoblast differentiation and matrix mineralization,and to explore the molecular mechanismof how PFMG1 functions through both animal and cellular experiments.METHODS For animal experiments,female BALB/c...
关键词: allergenicity chinese medicine injection serotonin
OBJECTIVE To explore the influence of ultrafiltration on the allergenicity of Naoluotai injection and H3 injectable powder in guinea pig.METHODS The ultra filtrated and non-ultra filtrated Naoluotai injection was utilized to do the sensitization test of guinea pig.The guinea pig was sensitized three times by subcutan...
关键词: hypoxia acute myocardial infarction ros mnsod apop
OBJECTIVE 3,5-Dimethoxy-4-(2-amino-3-prop-2-ynylsulfanyl-propionyl)-benzoic acid 4-guanidino-butyl ester(ZYZ451)showed excellent cardio-protective effects in our previous work.However,its therapeutic potential in vivo and the mechanism remained to be elucidated.Herein,we evaluated cardiac protective role of ZYZ451 in...
关键词: platelet aggregation adp receptors houxue huayu
Platelets aggregation and thrombosis formation are major reasons of cardiovascular and cerebral vascular diseases.To develop new generative,potent and safe agents for inhibiting platelet aggregation and preventing above diseases are urgently required.Some traditional Chinese medicines of″Houxue Huayu″have been show...
关键词: sesamol atherogenic ldl endothelial cell syrian ha
OBJECTIVE Highly electronegative L5 low-density lipoprotein(LDL),an atherogenic LDL,induces endothelial cell(EC)senescence and has been implicated in the progression of atherosclerosis.We examine whether sesamol,a natural organic compound and component of sesame oil,prevents EC senescence induced by electronegative L...
关键词: cymbopogon citratus stapf lipid atherogenic index
关键词: cymbopogon citratus stapf lipid profile diabetic a
关键词: salvianolic acid a isoproterenol myocardial infarc
OBJECTIVE To investigate the protective effect of salvianolic acid A(Sal A)on isoproterenol-induced myocardial infarction in mice and its possible mechanisms.METHODS The mice were subcutaneously injected with isopropranol(ISO 8mg·kg-1)to induce myocardial infarction and evaluated the myocardial protective effect of S...
关键词: cardiotoxicity ion channels action potentials card
OBJECTIVE Cardiotoxicity refers to drug-induced arrhythmia such as Torsades de pointes.Current single ion channel(hERG)-based assay generates-30% false results.The aim is to establish an advanced in vitro cardiotoxicity assay by incorporating high throughput multiple cardiac ion channel screening and human cardiomyoc...
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